11053-6
Lactate dehydrogenase [Enzymatic activity/volume] in Red Blood Cells
Active
Part Descriptions
LP15033-1 Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD).
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, D-lactate (Wikipedia)
LP15033-1 Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC 1.1.1.27) and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. PMID: 3882046. Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Lactate dehydrogenase
- Property
- CCnc
- Time
- Pt
- System
- RBC
- Scale
- Qn
- Method
Additional Names
- Short Name
- LDH RBC-cCnc
- Display Name
- LDH (RBC) [Catalytic activity/Vol]
- Consumer Name Alpha Get Info
- Lactate Dehydrogenase (LDH), Red blood cells
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 1.0j-a
- Last Updated
- Version 2.44
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Lactatdehydrogenase: Synonyms: LDH; |
| el-GR | Greek (Greece) | Γαλακτική αφυδρογονάση: Synonyms: LDH |
| es-MX | Spanish (Mexico) | Lactato deshidrogenasa: |
| es-AR | Spanish (Argentina) | lactato deshidrogenasa: |
| es-ES | Spanish (Spain) | Lactato deshidrogenasa: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Laktaadi dehüdrogenaas: Synonyms: Erütrotsüüdid Juhuslik Kvantitatiivne |
| fr-CA | French (Canada) | Lactate déshydrogénase: |
| fr-BE | French (Belgium) | Lactate déshydrogénase: Synonyms: LDH |
| fr-FR | French (France) | Lactate déhydrogénase: |
| it-IT | Italian (Italy) | Lattato deidrogenasi: Synonyms: Chimica Concentrazione Catalitica Globuli rossi Punto nel tempo (episodio) |
| ko-KR | Korean (Korea, Republic Of) | 젖산 탈수소효소: |
| nl-NL | Dutch (Netherlands) | lactaatdehydrogenase: Synonyms: rode bloedcellen |
| pl-PL | Polish (Poland) | Dehydrogenaza mleczanowa: |
| pt-BR | Portuguese (Brazil) | Desidrogenase Láctica: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Лактатдегидрогеназа: Synonyms: Каталитическая концентрация Количественный Точка во времени; |
| tr-TR | Turkish (Turkey) | Laktat dehidrojenaz: Synonyms: RBC |
| zh-CN | Chinese (China) | 乳酸脱氢酶: Synonyms: 2-羟基-丙酸; |
Example Units
| Unit | Source |
|---|---|
| U/mL{RBCs} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=11053-6
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright