Version 2.77

Part Description

LP15085-1   Pronormoblasts
A proerythroblast (or rubriblast, or pronormoblast) is the earliest of four stages in development of the normoblast.

In histology, it is very difficult to distinguish it from the other "-blast" cells (lymphoblast, myeloblast, monoblast, and megakaryoblast). The cytoplasm is blue in an H&E stain, indicating that it is basophilic.

Proerythroblasts arise from the CFU-e (colony-forming unit erythroid) cells, and give rise to basophilic erythroblasts. In the mouse, proerythroblasts are large committed progenitors that express high levels of transferrin receptor (iron acquisition receptor), the erythropoietin receptor (EpoR), some c-Kit (stem cell factor receptor), and are Ter119 (cell surface molecule)-positive. Their proliferative capacity is more limited compared to the preceding stage, the CFU-e.

In vivo, starting with the proerythroblast stage, erythroid cells undergo several more cell divisions while at the same time upregulating survival genes such as Bcl-xL, acquiring and storing large amounts of iron, ramping up the synthesis of hemoglobin and other erythroid genes (in large part a GATA-1 dependent process that is augmented by the EpoR signaling) and decreasing in cell size, eventually removing their nuclei and being released into the bloodstream as a reticulocyte. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Pronormoblasts/100 cells
Property
NFr
Time
Pt
System
Bone mar
Scale
Qn
Method
Manual count

Additional Names

Short Name
Pronormoblasts NFr Mar Manual
Display Name
Pronormoblasts/100 cells Manual cnt (BM)
Consumer Name Alpha Get Info
Pronormoblasts per 100 cells, Bone marrow

Basic Attributes

Class
HEM/BC
Type
Laboratory
First Released
Version 1.0j-a
Last Updated
Version 2.70
Change Reason
Changed method from "Microscopic" to make term consistent with other hematology differential terms. Test is still performed by microscopic observation.
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
47286-0 Differential panel - Bone marrow

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Proerythrobl.rel./KM
de-DE German (Germany) Pronormoblasten/100 Zellen:Anzahl pro Fraktion:Zeitpunkt:Knochenmark:Quantitativ:Manuelle Zählung
es-AR Spanish (Argentina) pronormoblastos/100 células:fracción de un número:punto en el tiempo:médula ósea:cuantitativo:microscopia
es-ES Spanish (Spain) Pronormoblastos/100 células:Fracción numérica:Punto temporal:Médula ósea:Qn:Contaje manual
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Pronormoblastos / 100 células:Fracción numérica:Punto temporal:Médula ósea:Cuantitativo:Conteo manual
fr-CA French (Canada) Pronormoblastes/100 cellules:Fraction numérique:Temps ponctuel:Moelle osseuse:Quantitatif:Numération manuelle
fr-FR French (France) Proérythroblastes/100 cellules:Fraction de nombres:Ponctuel:Moelle osseuse:Numérique:Comptage manuel
fr-BE French (Belgium) Pronormoblastes/100 cellules:Fraction numérique:Temps ponctuel:Moelle osseuse:Quantitatif:Numération manuelle
it-IT Italian (Italy) Pronormoblasti/100 cellule:NFr:Pt:Mid oss:Qn:Conta manuale
Synonyms: Ematologia (coagulazione) conta differenziale Frazione numerica Midollo osseo Punto nel tempo (episodio)
ko-KR Korean (Korea, Republic Of) 전적혈모구/100 세포:숫자분획:검사시점:골수:정량:현미경
nl-NL Dutch (Netherlands) pronormoblasten/100 cellen:getalsfractie:moment:beenmerg:kwantitatief:manuele telling
Synonyms: handmatige methode handmatige telling
pl-PL Polish (Poland) Pronormoblast/100 komórek:frakcja liczbowa:punkt w czasie:szpik kostny:ilościowy:zliczanie ręczne
Synonyms: Pronormoblast
pt-BR Portuguese (Brazil) Pronormoblastos/100 células:NFr:Pt:MedOssea:Qn:Microscopia
Synonyms: Pronormoblast; Rubriblast; Proerythroblast; Proerythroblasts; Early erythroblast; Cell; Cellularity; Gated cells; Fr; Number fraction; Percent; Point in time; Random; BM; Bone marrow; BON; Quantitative; QNT; Quant; Quan; Micro; Micros; Microscopic; HEMATOLOGY/CELL COUNTS; HEMATOLOGY/CELL COUNTS
ru-RU Russian (Russian Federation) Пронормобласты/100 клеток:КолДоля:ТчкВрм:Костный мозг:Колич:Ручной подсчет
Synonyms: Количественный Количество отношение Точка во времени;Момент
tr-TR Turkish (Turkey) Pronormoblastlar/100 hücre:SayFr:Zmlı:Kem il:Kant:Manuel sayım
Synonyms: El ile
zh-CN Chinese (China) 原红细胞/100 个细胞:计数型分数:时间点:骨髓:定量型:手工计数方法
Synonyms: 人工计数;人工计数方法;人工计数法;手工计数;手工计数法 前成红细胞;原始红;原始红细胞;原成红细胞;原正成红细胞;原红;早期成红细胞;早期成红血球细胞;早期有核红血球 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 实验室手工方法;手工;手工法;手工类实验室方法;手工类方法;手工类检验方法 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 经过门控分离的细胞 血液学/细胞计数;血液学与细胞计数 骨骼;骨头 髓

Example Units

Unit Source
% Example UCUM Units
% eCHN

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=11124-5