53561-7
Lactate dehydrogenase/Creatinine [Ratio] in Urine
Active
Part Descriptions
LP15033-1 Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD).
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Source: Wikipedia
, D-lactate (Wikipedia)
LP15033-1 Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC 1.1.1.27) and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. PMID: 3882046. Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition]
Source: Regenstrief LOINC
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database
, Creatinine
Fully-Specified Name
- Component
- Lactate dehydrogenase/Creatinine
- Property
- Ratio
- Time
- Pt
- System
- Urine
- Scale
- Qn
- Method
Additional Names
- Long Common Name
- Lactate dehydrogenase/Creatinine [Ratio] in Urine
- Short Name
- LDH/Creat Ur-Rto
- Display Name
- LDH/Creatinine (U) [Ratio]
- Consumer Name Alpha Get Info
- Lactate Dehydrogenase (LDH)/Creatinine, Urine
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.26
- Last Updated
- Version 2.70 (MIN)
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Lactatdehydrogenase/Creatinin: Synonyms: LDH |
| el-GR | Greek (Greece) | Γαλακτική αφυδρογονάση/Κρεατινίνη: Synonyms: Ratio Γαλακτική αφυδρογονάση Γαλακτικό οξύ Κρεατινίνη |
| es-ES | Spanish (Spain) | Lactato deshidrogenasa/Creatinina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Lactato deshidrogenasa / Creatinina: |
| et-EE | Estonian (Estonia) | Laktaadi dehüdrogenaas/kreatiniin: Synonyms: Juhuslik Kvantitatiivne Uriin |
| fr-CA | French (Canada) | Lactate déshydrogénase/Créatinine: |
| fr-FR | French (France) | Lactate déhydrogénase/créatinine: |
| fr-BE | French (Belgium) | Lactate déshydrogénase/Créatinine: Synonyms: LDH |
| it-IT | Italian (Italy) | Lattato deidrogenasi/Creatinina: Synonyms: Chimica Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | lactaatdehydrogenase/creatinine: Synonyms: kreatinine |
| pl-PL | Polish (Poland) | Dehydrogenaza mleczanowa/kreatynina: |
| pt-BR | Portuguese (Brazil) | Desidrogenase Láctica/Creatinina: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Лактатдегидрогеназа/Креатинин: Synonyms: Количественный Коэффициент; |
| tr-TR | Turkish (Turkey) | Laktat dehidrojenaz/Kreatinin: |
| zh-CN | Chinese (China) | 乳酸脱氢酶/肌酐: Synonyms: 2-羟基-丙酸; |
Example Units
| Unit | Source |
|---|---|
| U/g{creat} | Example UCUM Units |
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