Version 2.80

Term Description

This term should be used to report the narrative impression of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone 28-8. Patients with certain cancers, such as non-squamous non small cell lung cancer (NSCLC) or melanoma, whose tumors are positive for PD-L1 by 28-8 may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC: 83053-9], and the ordinal staining result using [LOINC: 83055-4]. This term was created for, but is not limited in use to, the Dako PD-L1 28-8 pharmDx test kit, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with certain cancers are eligible for nivolumab therapy.

Fully-Specified Name

Component
Programmed cell death ligand 1 by clone 28-8
Property
Imp
Time
Pt
System
Tiss
Scale
Nar
Method
Immune stain

Additional Names

Long Common Name
PD-L1 by clone 28-8 [Interpretation] in Tissue by Immune stain Narrative
Short Name
PD-L1 by 28-8 Tiss ImStn-Imp
Display Name
PD-L1 by clone 28-8 Immune stain Nar (Tiss) [Interp]
Consumer Name Alpha Get Info
Interpretation of PD-L1 by clone 28-8 test result, Tissue

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58 (ADD)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 από τον κλώνο 28-8:Imp:Pt:Ιστός:Nar:Ανοσολογική χρώση
Synonyms: Imp Συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 από τον κλώνο 28-8
es-ES Spanish (Spain) Ligando 1 de la molécula de muerte programada por el clon 28-8 (PD-L1 clon 28-8):Impresión/interpretación del estudio:Punto temporal:Tejido:Narrativo:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Ligando 1 de muerte celular programada por el clon 28-8:Impresión / interpretación del estudio:Punto temporal:Tejido y frotis:Narrativo:Mancha inmune
it-IT Italian (Italy) Morte cellulare programmata ligando 1 tramite clone 28-8:Imp:Pt:Tessuto:Nar:Colorazione immunologica
Synonyms: Impressione/interpretazione di studio Patologia PD-L1 tramite clone 28-8 Punto nel tempo (episodio) Tessuto & Strisci
zh-CN Chinese (China) 采用克隆 28-8 所测定的程序性死亡配体 1:印象:时间点:组织与涂片:叙述型:免疫染色法
Synonyms: Ⅰ I 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法 采用克隆（PD-L1抗体克隆） 28-8 所测定的 PD-L1

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83056-2